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May 28, 2003

Analysis of Generic Nevirapine Products in Developing CountriesRESEARCH LETTER

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2003;289(20):2648-2649. doi:10.1001/jama.289.20.2648-c

To the Editor: Combination antiretroviral therapy (CART) can dramatically improve the prognosis of patients with human immunodeficiency virus (HIV), but 90% of infected individuals worldwide do not have access to these drugs.1 Although generic drugs are now available in many countries at costs that are considerably lower than those of discounted proprietary agents, there have been anecdotal reports of generic antiviral medications that contain little or no active ingredients.2,3 As part of a quality-assurance investigation, we analyzed the content of several generic and proprietary antiretroviral formulations containing the non-nucleoside reverse transcriptase inhibitor nevirapine.

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