Letters Section Editor: Stephen J. Lurie,
MD, PhD, Senior Editor.
To the Editor: We have 2 concerns about the
study of Mr Rathore and colleagues.1 First,
about 70% of ingested digoxin is eliminated renally.2 Nonetheless,
the small differences in glomerular filtration rate and in dosing between
the 3 digoxin groups reported by Rathore et al, although statistically significant,
certainly do not explain the more than 2-fold increase in SDCs between groups.
de Denus S, Spinler SA. Optimal Digoxin Concentrations for Patients With Heart FailureOptimal Digoxin Concentrations for Patients With Heart Failure. JAMA. 2003;289(20):2643. doi:10.1001/jama.289.20.2643-a