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June 4, 2003

Acetylcysteine and Renal Function Following Coronary Angiographic ProceduresAcetylcysteine and Renal Function Following Coronary Angiographic Procedures

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2003;289(21):2794-2796. doi:10.1001/jama.289.21.2794-a

To the Editor: Dr Kay and colleagues1 found that in patients with moderate renal insufficiency undergoing coronary angiography, prophylactic use of acetylcysteine with hydration resulted in an 8% absolute risk reduction in the incidence of contrast-induced nephropathy. Despite promising results from additional similar trials with acetylcysteine,2,3 we are concerned about how the primary end point was defined in this study.

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