Letters Section Editor: Stephen J. Lurie,
MD, PhD, Senior Editor.
To the Editor: Dr Kay and colleagues1 found that in patients with moderate renal insufficiency
undergoing coronary angiography, prophylactic use of acetylcysteine with hydration
resulted in an 8% absolute risk reduction in the incidence of contrast-induced
nephropathy. Despite promising results from additional similar trials with
acetylcysteine,2,3 we are
concerned about how the primary end point was defined in this study.
Bagshaw SM, Culleton BF. Acetylcysteine and Renal Function Following Coronary Angiographic ProceduresAcetylcysteine and Renal Function Following Coronary Angiographic Procedures. JAMA. 2003;289(21):2794-2796. doi:10.1001/jama.289.21.2794-a