[Skip to Content]
[Skip to Content Landing]
Contempo Updates
Clinician's Corner
June 25, 2003


Author Affiliations

Author Affiliation: Department of Internal Medicine, University of Iowa College of Medicine and Veterans Administration Medical Center, Iowa City (Drs Thomas and Hunninghake).


Contempo Updates Section Editor: Sarah Pressman Lovinger, MD, Fishbein Fellow.

JAMA. 2003;289(24):3300-3303. doi:10.1001/jama.289.24.3300

Sarcoidosis is a systemic inflammatory disease that occurs throughout the world and affects people of all races and ages. Despite years of study and many recent advances in diagnostic strategies, the etiology of sarcoidosis remains unknown. The disease is characterized pathologically by the presence of noncaseating granulomas in affected organs. These granulomas can occur with varying rates in any organ system, but most commonly are found in the lung and lymph nodes. Patients with sarcoidosis may be entirely asymptomatic or can have a wide range of constitutional and other nonspecific symptoms. The wide spectrum of affected patients, variability in organ involvement, absence of specific symptoms, and unidentified etiology combine to make sarcoidosis both a diagnostic and a therapeutic challenge.

First Page Preview View Large
First page PDF preview
First page PDF preview