Letters Section Editor: Stephen J. Lurie,
MD, PhD, Senior Editor.
To the Editor: Dr Blackman and colleagues1 found that administration of growth hormone (GH)
to elderly men and women increased lean body mass and decreased fat mass,
but that it also was associated with a high frequency of adverse effects.
Their GH dose of 90 mg, however, far exceeds the usual dose of 18 to 33 mg
that is commonly used in clinical practice.2 It
is not surprising that a large number of patients experienced adverse effects
while receiving this higher dose. My practice has treated more than 100 patients
with GH therapy and only 1% to 2% have been found to have increased levels
of blood glucose. In my experience, any increase in levels of glycohemoglobin
that might occur from GH therapy quickly corrects when the dose is lowered.
Braverman E. Use of Growth Hormone in Elderly Individuals. JAMA. 2003;290(4):462. doi:10.1001/jama.290.4.462-a