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August 6, 2003

Premature Termination of Clinical Trials

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2003;290(5):595. doi:10.1001/jama.290.5.595-a

To the Editor: Drs Psaty and Rennie1 discussed ethical imperatives against premature discontinuation of clinical trials for financial reasons. They argued that this causes harm by breaking the implicit and explicit agreements with research participants, investigators, and the oversight bodies that approved the protocol. Although the authors focused on industry-sponsored trials, their arguments actually apply to all clinical research regardless of sponsorship.

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