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August 6, 2003

Bronchiolitis Obliterans in a Survivor of a Chemical Weapons Attack

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2003;290(5):598-599. doi:10.1001/jama.290.5.598

To the Editor: Bronchiolitis obliterans develops when an injury of small conducting airways leads to the proliferation of granulation tissue and obliteration of the airway lumen. The histological pattern is nonspecific and can result from multiple etiologies. The clinical presentation is divided into 5 categories: toxic fume inhalation, postinfectious, connective tissue disease–associated, localized, and idiopathic.1 Several substances have been reported to cause bronchiolitis obliterans through inhalation of toxic fumes. The distribution of these agents in the lung is determined by the size of the molecule, the duration of exposure, and the solubility of the agent.2

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