Author Affiliations: Chest Pain Center, Division of Cardiovascular Diseases, University of Alabama at Birmingham.
Conventional wisdom (or misconception) holds that the 4 major modifiable
traditional cardiovascular risk factors—smoking, diabetes mellitus,
hypertension, and hypercholesterolemia—account for "only 50%" of those
who go on to develop coronary heart disease (CHD),1,2 even
though the original source of this claim is not well documented. Thus, over
the past decade, a search to discover novel markers and other nontraditional
risk factors to assess cardiovascular risk has come to the forefront.
Canto JG, Iskandrian AE. Major Risk Factors for Cardiovascular DiseaseDebunking the "Only 50%" Myth. JAMA. 2003;290(7):947-949. doi:10.1001/jama.290.7.947