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August 20, 2003

Issues in Statin-Associated Myopathy—Reply

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2003;290(7):888. doi:10.1001/jama.290.7.888-a

To the Editor: Dr Thompson and colleagues1 reported that 7% of cases of statin-induced rhabdomyolysis in the US Food and Drug Administration (FDA) Qscan database from November 1997 through March 2000 were associated with a coprescription for macrolide antibiotics. Such coprescriptions, however, only accounted for 3% of such incidents between January 1990 and March 2002. It is unclear whether this represents a class effect or is due only to specific macrolide antibiotics.

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