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August 20, 2003

Issues in Statin-Associated Myopathy

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2003;290(7):888. doi:10.1001/jama.290.7.888-a

In Reply: In response to Drs Luh and Karnath, reanalysis of the FDA database by individual antibiotics demonstrates that clarithromycin, azithromycin, and erythromycin are all associated with statin-associated rhabdomyolysis. Clarithromycin was associated with 3.2% of cases of statin-associated myopathy, azithromycin with 2.1%, and erythromycin with 1.8% in the FDA database from November 1997 through March 2000. The respective associations were 1.8%, 0.5%, and 0.6% of cases from January 1990 through March 2002.

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