Letters Section Editor: Stephen J. Lurie,
MD, PhD, Senior Editor.
To the Editor: Drs Al-Khatib and colleagues1 described mesoridazine as having an unknown potential
for causing QT prolongation. Mesoridazine is a metabolite of thioridazine,
which the authors indicate as having a very probable potential for causing
I would appreciate the authors' comments regarding using drugs with
an unknown potential of causing QT prolongation, particularly mesoridazine.
It seems inconsistent to make no recommendations to obtain an ECG before using
mesoridazine but to recommend one before using haloperidol, risperidone, or
Cappuccio C. Medications That Prolong the QT IntervalMedications That Prolong the QT Interval. JAMA. 2003;290(8):1025. doi:10.1001/jama.290.8.1025-a