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September 24, 2003

Leukoreduction vs Buffy-Coat Depletion and the Safety of Blood Transfusion

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2003;290(12):1580. doi:10.1001/jama.290.12.1580-a

To the Editor: Dr Hébert and colleagues1 found that a national universal leukoreduction program for red blood cell (RBC) transfusion reduced the rates of mortality and morbidity after RBC transfusions in high-risk patients. Although the authors state that RBCs transfused in the period before the introduction of the policy were stored in an additive solution, they do not indicate whether any of these units underwent depletion of the buffy coat. It also would be important to know about clinical use of microaggregate filters at the bedside.

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