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September 24, 2003


Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2003;290(12):1581-1582. doi:10.1001/jama.290.12.1581

To the Editor: Several epidemiologic studies have found an association between the presence of an apolipoprotein E (APOE) ∊4 allele and increased risk for Alzheimer disease (AD). Although 2 brain imaging studies of middle-aged and elderly individuals have found that the ∊4 allele is associated with an AD-like pattern on positron emission tomogrophy (PET) brain scans,1,2 we are not aware of any study has that has examined this association in young individuals.

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