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October 1, 2003

Adipocytokines in Synovial FluidRESEARCH LETTER

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2003;290(13):1709-1710. doi:10.1001/jama.290.13.1709-c

To the Editor: Adipocytes secrete several highly active molecules including leptin, adiponectin, and resistin. These substances, collectively known as adipocytokines, may function as signaling molecules that influence insulin sensitivity of peripheral tissues.1

Adiponectin belongs to the C1q/tumor necrosis factor-α molecular superfamily and is regarded as a novel molecule coupling energy balance and metabolism with immune function and defense.2 Resistin was initially described as an adipocyte-derived mediator of hepatic insulin resistance and is regulated by peroxisome proliferator-activated receptor gamma and CCAAT-enhancer binding proteins.3 Because activation of the local complement system is involved in the pathogenesis of rheumatoid athritis (RA)4 and because cytokine production has been detected in the infrapatellar fat pad,5 we investigated whether adiponectin and resistin can be detected in synovial fluid of the knee and whether their presence differs in patients with RA vs those with osteoarthritis (OA).

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