[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Citations 0
October 1, 2003

Effects of Estrogen Plus Progestin on Risk of DementiaEffects of Estrogen Plus Progestin on Risk of Dementia

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2003;290(13):1706-1708. doi:10.1001/jama.290.13.1706-a

To the Editor: Although the results of the WHIMS trial1 may seem surprising, they are consistent with the results of previous observational studies of hormone therapy and risk of AD.

In their case-control study, Brenner et al2 found no relationship between incident AD and use of hormone therapy within a 10-year interval. Similar 10-year results were reported from the UK General Practice Research Database.3 By contrast, 2 prospective studies4,5 have suggested that lifetime hormone use (presumably including perimenopausal and early postmenopausal use) may be beneficial.

First Page Preview View Large
First page PDF preview
First page PDF preview