Letters Section Editor: Stephen J. Lurie,
MD, PhD, Senior Editor.
To the Editor: Although the results of the
WHIMS trial1 may seem surprising, they are
consistent with the results of previous observational studies of hormone therapy
and risk of AD.
In their case-control study, Brenner et al2 found
no relationship between incident AD and use of hormone therapy within a 10-year
interval. Similar 10-year results were reported from the UK General Practice
Research Database.3 By contrast, 2 prospective
studies4,5 have suggested
that lifetime hormone use (presumably including perimenopausal and early postmenopausal
use) may be beneficial.
Breitner JCS, Zandi PP. Effects of Estrogen Plus Progestin on Risk of DementiaEffects of Estrogen Plus Progestin on Risk of Dementia. JAMA. 2003;290(13):1706-1708. doi:10.1001/jama.290.13.1706-a