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October 1, 2003

Effects of Estrogen Plus Progestin on Risk of DementiaEffects of Estrogen Plus Progestin on Risk of Dementia

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2003;290(13):1706-1708. doi:10.1001/jama.290.13.1706-a

To the Editor: Although the results of the WHIMS trial1 may seem surprising, they are consistent with the results of previous observational studies of hormone therapy and risk of AD.

In their case-control study, Brenner et al2 found no relationship between incident AD and use of hormone therapy within a 10-year interval. Similar 10-year results were reported from the UK General Practice Research Database.3 By contrast, 2 prospective studies4,5 have suggested that lifetime hormone use (presumably including perimenopausal and early postmenopausal use) may be beneficial.

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