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October 1, 2003

Effects of Estrogen Plus Progestin on Risk of DementiaEffects of Estrogen Plus Progestin on Risk of Dementia

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2003;290(13):1706-1708. doi:10.1001/jama.290.13.1706-a

To the Editor: We have 2 concerns about the design of the WHIMS trial.1 First, the authors grouped a number of unrelated causes of dementia, including AD, vascular dementia, hydrocephalus, Parkinson disease, and alcohol related dementias, into a single outcome variable. It may not be valid to group all "probable dementias" into a single category for statistical analysis. While the WHIMS groups (hormone therapy and placebo) were significantly different for the incidence of probable dementia, the number of cases in the subgroups was too small to be clinically relevant.

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