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October 1, 2003

Natural vs Vaccine-Acquired Immunity to Cytomegalovirus—Reply

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2003;290(13):1709. doi:10.1001/jama.290.13.1709-c

To the Editor: Dr Fowler and colleagues1 found that naturally acquired immunity to cytomegalovirus (CMV) among pregnant women resulted in a 69% reduction in the risk of congenital CMV to their offspring. They inferred that vaccine-induced infection would be of the same magnitude. However, this may be an underestimate because intrauterine infection of infants transmitted from seropositive mothers may result either from reinfection or reactivation of latent virus.

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