Letters Section Editor: Stephen J. Lurie,
MD, PhD, Senior Editor.
To the Editor: Dr Fowler and colleagues1 found that naturally acquired immunity to cytomegalovirus
(CMV) among pregnant women resulted in a 69% reduction in the risk of congenital
CMV to their offspring. They inferred that vaccine-induced infection would
be of the same magnitude. However, this may be an underestimate because intrauterine
infection of infants transmitted from seropositive mothers may result either
from reinfection or reactivation of latent virus.
Plotkin SA. Natural vs Vaccine-Acquired Immunity to Cytomegalovirus—Reply. JAMA. 2003;290(13):1709. doi:10.1001/jama.290.13.1709-c