Letters Section Editor: Stephen J. Lurie,
MD, PhD, Senior Editor.
To the Editor: Ozone, an oxidant of photochemical
smog, is known to cause a variety of respiratory effects, including diminished
lung function, exacerbation of respiratory symptoms, and inflammation of airways.1
To date, lung inflammation has been measured only invasively, by analysis
of bronchoalveolar lavage fluid obtained from adults exposed to relatively
high concentrations of ozone while exercising.2,3 We
used exhaled nitric oxide4 to measure the relationship between
ambient ozone levels and inflammation of airways.
Nickmilder M, Carbonnelle S, de Burbure C, Bernard A. Relationship Between Ambient Ozone and Exhaled Nitric Oxide in Children. JAMA. 2003;290(19):2546-2547. doi:10.1001/jama.290.19.2546-a