November 26, 2003

Inhibition of SARS-Associated Coronavirus Infection and Replication by RNA Interference

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2003;290(20):2665-2666. doi:10.1001/jama.290.20.2665

To the Editor: A novel coronavirus has been identified as the etiologic agent of severe acute respiratory syndrome (SARS),13 for which there is no specific treatment. Small interfering RNAs (siRNAs) are double-stranded RNAs that direct sequence-specific degradation of messenger RNA in mammalian cells.4 It is also possible, however, that siRNAs could specifically interfere with viral RNA.

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