Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.
To the Editor: A novel coronavirus has been
identified as the etiologic agent of severe acute respiratory syndrome (SARS),1- 3 for which there
is no specific treatment. Small interfering RNAs (siRNAs) are double-stranded
RNAs that direct sequence-specific degradation of messenger RNA in mammalian
cells.4 It is also possible, however, that
siRNAs could specifically interfere with viral RNA.
He M, Zheng B, Peng Y, Peiris JSM, Poon LLM, Yuen KY, Lin MCM, Kung H, Guan Y. Inhibition of SARS-Associated Coronavirus Infection and Replication by RNA Interference. JAMA. 2003;290(20):2665-2666. doi:10.1001/jama.290.20.2665