To the Editor: Dr Szapary and colleagues1 reported that 8 weeks of treatment with guggulipid
did not appear to improve levels of serum cholesterol among adults with hypercholesterolemia.
They also found that guggulipid was associated with higher levels of low-density
lipoprotein cholesterol (LDL-C). We are concerned that preparations of guggulsterones
may contain many other substances that can inhibit the absorption and biodisposability
of active substances. The gum resin of Commiphora mukul, from which guggulipid is derived, has been found to contain a complex
mixture of compounds.2,3
Firenzuoli F, Gori L. Guggulipid and Cholesterol Levels—Reply. JAMA. 2003;290(21):2800. doi:10.1001/jama.290.21.2800-a