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December 3, 2003

Guggulipid and Cholesterol Levels—Reply

JAMA. 2003;290(21):2800. doi:10.1001/jama.290.21.2800-a

To the Editor: Dr Szapary and colleagues1 reported that 8 weeks of treatment with guggulipid did not appear to improve levels of serum cholesterol among adults with hypercholesterolemia. They also found that guggulipid was associated with higher levels of low-density lipoprotein cholesterol (LDL-C). We are concerned that preparations of guggulsterones may contain many other substances that can inhibit the absorption and biodisposability of active substances. The gum resin of Commiphora mukul, from which guggulipid is derived, has been found to contain a complex mixture of compounds.2,3

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