Letters Section Editor: Stephen J. Lurie,
MD, PhD, Senior Editor.
To the Editor: Dr Als-Nielsen and colleagues1 concluded that trials funded by for-profit organizations
are more likely to have positive conclusions due to biased interpretation
of trial results. Although Als-Nielsen et al found that trials funded by for-profit
organizations more often demonstrate increased differences compared with control
groups, they found that such trials are more likely to use placebos as a control,
report a higher frequency of adverse effects, reach preplanned numbers of
subjects, and be published in high-impact journals.
Waldorff S. Results of Clinical Trials Sponsored by For-Profit vs Nonprofit EntitiesResults of Clinical Trials Sponsored by For-Profit vs Nonprofit Entities. JAMA. 2003;290(23):3070. doi:10.1001/jama.290.23.3070-a