Clinicians have long known that ozone, an intensely irritating and reactive
component of air pollution, can have harmful respiratory effects. Now, a team
of US and Swiss scientists has found that ozone produced within the body may
contribute to atherosclerosis (Science. 2003;302:1053-1056) .
The researchers previously discovered that antibodies can generate ozone
if they are supplied with a reactive form of oxygen that can be provided by
neutrophils. They realized that since both neutrophils and antibodies have
an opportunity to interact during inflammatory responses, ozone produced by
antibodies might contribute to the damage caused by inflammatory diseases
such as atherosclerosis.
Stephenson J. Ozone and Arterial Disease. JAMA. 2003;290(23):3057. doi:10.1001/jama.290.23.3057-a