Letters Section Editor: Stephen J. Lurie,
MD, PhD, Senior Editor.
To the Editor: Dr Wagner and colleagues1 concluded that "sertraline is an effective, safe,
and well-tolerated short-term treatment for children and adolescents with
MDD [major depressive disorder]." We have some questions about their methods.
First, the authors did not mention whether they assessed substance abuse
or whether individuals with substance abuse were excluded from their study.
Mathews M, Mathews M, Mathews J. Efficacy of Sertraline in the Treatment of Children and Adolescents With Major Depressive Disorder. JAMA. 2004;291(1):40. doi:10.1001/jama.291.1.40-a