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January 7, 2004

Efficacy of Sertraline in the Treatment of Children and Adolescents With Major Depressive Disorder

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2004;291(1):40. doi:10.1001/jama.291.1.40-a

To the Editor: Dr Wagner and colleagues1 concluded that "sertraline is an effective, safe, and well-tolerated short-term treatment for children and adolescents with MDD [major depressive disorder]." We have some questions about their methods.

First, the authors did not mention whether they assessed substance abuse or whether individuals with substance abuse were excluded from their study.

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