Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.
In Reply: I agree with Dr Krivoy and colleagues
that a search is underway for an alternative or adjunct to diazepam as an
antiseizure treatment. Shih and McDonough1 have
shown that its effectiveness is decreased when administered 40 minutes after
seizure onset. However, in another study McDonough et al2 also
found that diazepam was the most potent compound when administered 40 minutes
after seizure onset compared with 8 anticholinergic drugs, including benactyzine.
Lee EC. Treatment of Sarin Exposure—Reply. JAMA. 2004;291(2):181. doi:10.1001/jama.291.2.182-b