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January 21, 2004

Antibiotics and Coronary Heart Disease

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2004;291(3):302. doi:10.1001/jama.291.3.302-b

To the Editor: Dr O'Connor and colleagues1 found no benefit of azithromycin in the secondary prevention of CHD. In their accompanying Editorial, Drs Pislaru and Van de Werf2 suggested that either C pneumoniae does not play a role in atherogenesis or that perhaps the proper antibiotic regimen was not used. Thus, Pislaru and Van de Werf recommend waiting for the results of ongoing trials with different antibiotic treatment regimens before embracing the first explanation.

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