Letters Section Editor: Stephen J. Lurie,
MD, PhD, Senior Editor.
To the Editor: Dr O'Connor and colleagues1 found no benefit of azithromycin in the secondary
prevention of CHD. In their accompanying Editorial, Drs Pislaru and Van de
Werf2 suggested that either C pneumoniae does not play a role in atherogenesis or that perhaps
the proper antibiotic regimen was not used. Thus, Pislaru and Van de Werf
recommend waiting for the results of ongoing trials with different antibiotic
treatment regimens before embracing the first explanation.
Nieto FJ. Antibiotics and Coronary Heart Disease. JAMA. 2004;291(3):302. doi:10.1001/jama.291.3.302-b