Letters Section Editor: Stephen J. Lurie,
MD, PhD, Senior Editor.
To the Editor: Dr Harris and colleagues1 found that methotrexate treatment failed to maintain
the hearing improvement achieved with high dose glucocorticoid treatment in
patients with autoimmune inner ear disease (AIED). Several of these authors
have previously written about the association between AIED and a serum antibody
to a 68-kDa bovine inner ear protein (subsequently identified as inducible
heat shock protein 70 (HSP70).2,3 It
would be of interest to know how many of the patients who underwent the prednisone
challenge had this serum antibody, and whether responsiveness to glucorticoid
was related to presence of the antibody, as previously reported.3 Similarly,
the authors should report the prevalence of the antibody among patients in
the methotrexate and placebo groups.
Bloch KJ. Serologic Factors in Autoimmune Ear Disease. JAMA. 2004;291(3):303. doi:10.1001/jama.291.3.303-c