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January 28, 2004

Genetic vs Hormonal Factors in Lipid Metabolism in Women

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2004;291(4):424-425. doi:10.1001/jama.291.4.424-c

To the Editor: In their Research Letter, Dr Cooley and colleagues1 reported that healthy, young, nonobese women with Turner syndrome had more atherogenic lipid profiles than did 46,XX women of the same age and body composition with premature ovarian failure. The authors concluded that the atherogenic lipid profile in Turner syndrome may be caused by haploinsufficiency for a yet-undescribed gene on the X chromosome. Premature ovarian failure, however, is a poorly understood condition with multiple etiologies. In addition to autoimmune or virally mediated ovarian failure, some of the women with premature ovarian failure syndrome were likely to have a mosaic pattern.2 Thus, it is unclear that the authors' findings are related to a specific genotype.

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