Letters Section Editor: Stephen J. Lurie,
MD, PhD, Senior Editor.
To the Editor: In their Research Letter, Dr
Cooley and colleagues1 reported that healthy,
young, nonobese women with Turner syndrome had more atherogenic lipid profiles
than did 46,XX women of the same age and body composition with premature ovarian
failure. The authors concluded that the atherogenic lipid profile in Turner
syndrome may be caused by haploinsufficiency for a yet-undescribed gene on
the X chromosome. Premature ovarian failure, however, is a poorly understood
condition with multiple etiologies. In addition to autoimmune or virally mediated
ovarian failure, some of the women with premature ovarian failure syndrome
were likely to have a mosaic pattern.2 Thus,
it is unclear that the authors' findings are related to a specific genotype.
Taylor HS. Genetic vs Hormonal Factors in Lipid Metabolism in Women. JAMA. 2004;291(4):424-425. doi:10.1001/jama.291.4.424-c