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Medical News and Perspectives
February 4, 2004

Ebola Vaccines Tested in Humans, Monkeys

JAMA. 2004;291(5):549-550. doi:10.1001/jama.291.5.549

While the World Health Organization is helping to contain another outbreak of Ebola hemorrhagic fever in West Africa—the fifth in two years—two vaccine candidates are raising hope that the world's deadliest virus will soon be tamed .

The first, a DNA "primer" containing DNA from the three known strains of Ebola virus, was injected into volunteers starting in November 2002. Its creators, mainly at the National Institutes of Health (NIH) envision it as stage one of a "prime-boost" strategy, with the booster using an adenovirus to smuggle additional Ebola virus DNA into antigen-presenting immune cells.

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