While the World Health Organization is helping to contain another outbreak
of Ebola hemorrhagic fever in West Africa—the fifth in two years—two
vaccine candidates are raising hope that the world's deadliest virus will
soon be tamed .
The first, a DNA "primer" containing DNA from the three known strains
of Ebola virus, was injected into volunteers starting in November 2002. Its
creators, mainly at the National Institutes of Health (NIH) envision it as
stage one of a "prime-boost" strategy, with the booster using an adenovirus
to smuggle additional Ebola virus DNA into antigen-presenting immune cells.
Vastag B. Ebola Vaccines Tested in Humans, Monkeys. JAMA. 2004;291(5):549-550. doi:10.1001/jama.291.5.549