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Special Communication
February 4, 2004

Ethical Issues Concerning Research in Complementary and Alternative Medicine

Author Affiliations

Author Affiliations: Department of Clinical Bioethics, Warren Grant Magnuson Clinical Center (Drs Miller and Emanuel); Office of the Clinical Director, National Institute of Mental Health (Dr Rosenstein); and National Center for Complementary and Alternative Medicine (Dr Straus), National Institutes of Health, Bethesda, Md.

JAMA. 2004;291(5):599-604. doi:10.1001/jama.291.5.599
Abstract

The use of complementary and alternative medicine (CAM) has grown dramatically in recent years, as has research on the safety and efficacy of CAM treatments. Minimal attention, however, has been devoted to the ethical issues relating to research on CAM. We argue that public health and safety demand rigorous research evaluating CAM therapies, research on CAM should adhere to the same ethical requirements for all clinical research, and randomized, placebo-controlled clinical trials should be used for assessing the efficacy of CAM treatments whenever feasible and ethically justifiable. In addition, we explore the legitimacy of providing CAM and conventional therapies that have been demonstrated to be effective only by virtue of the placebo effect.

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