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Letters
February 11, 2004

Effectiveness of Influenza Vaccine to Prevent Acute Otitis Media

Author Affiliations
 

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2004;291(6):692-694. doi:10.1001/jama.291.6.692-c

To the Editor: Dr Hoberman and colleagues1 concluded that influenza vaccine did not reduce the occurrence of acute otitis media (AOM) in children. Unfortunately, the low incidence of influenza in their cohorts limits the conclusions from the study.

The authors' primary end point—the number of children with at least 1 episode of AOM—may miss a clinically significant effect of vaccination. For example, if during a given period unvaccinated children would experience 2 episodes of AOM and the vaccinees only 1 episode, this would constitute a 50% reduction in AOM in the vaccine group. Thus, it could have been expected that there would have been no difference between groups in this end point.

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