Letters Section Editor: Stephen J. Lurie,
MD, PhD, Senior Editor.
To the Editor: Dr Hoberman and colleagues1 reported that trivalent influenza vaccine did not
reduce the risk of AOM among children aged 6 to 24 months. This finding is
in contrast with the findings from 4 previous reports2- 5 in
which use of the vaccine was associated with an approximate one-third reduction
in AOM occurrence. Two important considerations are missing from the article
by Hoberman et al. First, the authors did not address the efficacy of the
vaccine in preventing influenza-associated AOM. As many as two thirds of children
with influenza may have AOM.2 The benefit
of influenza vaccine derives directly from prevention of influenza-induced
AOM cases. In the study by Hoberman et al, 50 children had proven influenza;
it would be important to know the efficacy of the vaccine in preventing influenza-induced
AOM in these cases.
Chonmaitree T, Grady J. Effectiveness of Influenza Vaccine to Prevent Acute Otitis Media. JAMA. 2004;291(6):692-694. doi:10.1001/jama.291.6.693-a