Letters Section Editor: Stephen J. Lurie,
MD, PhD, Senior Editor.
To the Editor: Worldwide, pre-eclampsia is
a leading cause of maternal death, affecting 3% to 5% of all pregnancies.1 Recently, elevated plasma concentrations of the
endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine (ADMA)
have been linked to pre-eclampsia and impaired endothelial function.2- 5
Maas R, Böger RH, Schwedhelm E, Casas JP, López-Jaramillo P, Serrano N, Díaz LA. Plasma Concentrations of Asymmetric Dimethylarginine (ADMA) in Colombian Women With Pre-eclampsia. JAMA. 2004;291(7):823-824. doi:10.1001/jama.291.7.823