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Health Agencies Update
February 25, 2004

Stifling Subsequent Strokes

JAMA. 2004;291(8):933. doi:10.1001/jama.291.8.933-a

Experiencing a mild stroke may alter the brain in such a way that serves to protect it from future attacks, according to research funded by the National Institute of Neurological Disorders and Stroke (Lancet. 2003;362:1028-1037).

The researchers found that "preconditioned" mice—animals that had transient ischemic attacks caused when the cerebral artery was blocked for 15 minutes—experienced a 70% decrease in brain damage during a second, larger attack compared with control mice. The authors suggest that a preconditioned mouse experiences altered expression of certain genes in anticipation of a future, larger stroke.

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