Letters Section Editor: Stephen J. Lurie,
MD, PhD, Senior Editor.
In Reply: In response to Dr Ananth and colleagues,
the primary purpose of reporting the combined outcome of death or substantial
gross motor dysfunction is because the 2 components represent competing risks—a
child cannot have motor dysfunction at 2 years if he or she has already died.
Because we had found a significantly reduced number of survivors with gross
motor dysfunction (reduced from 6.6% to 3.4%) it was important to establish
that this was not achieved through an excess of deaths in the magnesium group.
Crowther CA, Hiller JE, Doyle LW, Haslam RR. Magnesium Sulfate for Preterm Neuroprotection—Reply. JAMA. 2004;291(8):940-941. doi:10.1001/jama.291.8.941-a