Letters Section Editor: Stephen J. Lurie,
MD, PhD, Senior Editor.
In Reply: In response to Drs Andrikopoulos
and Richter, the main finding of our study is that families with exceptional
longevity have a lipoprotein signature that includes high levels of HDL cholesterol
and large HDL and LDL lipoprotein particle sizes. These lipoprotein phenotypes
were demonstrated to be associated with decreased prevalence of hypertension,
cardiovascular disease (CVD), and the metabolic syndrome. Our study and other
studies1 have clearly documented CVD-protective
effects of the same lipoprotein phenotypes. Thus, our finding with respect
to exceptional longevity and lipoprotein concentrations and particle sizes
appears robust and consistent with the burden of the cardiovascular literature.
Barzilai N, Atzmon G, Schechter C, Lipton R, Shuldiner AR. Genetic Factors in Exceptional Longevity—Reply. JAMA. 2004;291(8):941-943. doi:10.1001/jama.291.8.942