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February 25, 2004

Genetic Factors in Exceptional Longevity—Reply

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2004;291(8):941-943. doi:10.1001/jama.291.8.942

In Reply: In response to Drs Andrikopoulos and Richter, the main finding of our study is that families with exceptional longevity have a lipoprotein signature that includes high levels of HDL cholesterol and large HDL and LDL lipoprotein particle sizes. These lipoprotein phenotypes were demonstrated to be associated with decreased prevalence of hypertension, cardiovascular disease (CVD), and the metabolic syndrome. Our study and other studies1 have clearly documented CVD-protective effects of the same lipoprotein phenotypes. Thus, our finding with respect to exceptional longevity and lipoprotein concentrations and particle sizes appears robust and consistent with the burden of the cardiovascular literature.

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