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March 3, 2004

Olanzapine vs Haloperidol for Treatment of Schizophrenia

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2004;291(9):1064. doi:10.1001/jama.291.9.1064-b

To the Editor: Dr Rosenheck and colleagues1 reported that olanzapine did not demonstrate advantages compared with haloperidol (in combination with prophylactic benztropine) in compliance, symptoms, extrapyramidal symptoms, or overall quality of life among patients with schizophrenia or schizoaffective disorder The authors also found that olanzapine was associated with better cognitive function and motor function (including less tardive dyskinesia) than haloperidol, but also with greater weight gain.

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