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March 3, 2004

Management of Chronic Obstructive Pulmonary Disease

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2004;291(9):1066. doi:10.1001/jama.291.9.1066-b

To the Editor: Dr Sin and colleagues1 appear to have double-counted participants in 2 reported trials of tiotropium. Figure 2 of their article suggests that each tiotropium trial was treated independently. In actuality, Brusasco et al2 appeared to report the combined results of Donohue et al3 and another unpublished trial, and Vincken et al4 appeared to report the combined results from van Noord et al5 and a separate unpublished trial. The total number of patients randomized in the cited trials was therefore 2663, not 3574 as stated in the article. Neither of the composite trials referenced the earlier publications with which they had overlapping participants.

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