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Letters
March 10, 2004

Optimal Control of Glycemia Among Critically Ill Patients—Reply

Author Affiliations
 

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2004;291(10):1198-1199. doi:10.1001/jama.291.10.1199-a

In Reply: In response to Drs Van den Berghe and Bouillon, we indicated that APACHE II scores, SOFA scores, and reason for admission were all included in the logistic regression analysis. Age was removed as it did not improve the model fit, possibly because it is already contained within the APACHE II instrument. Consequently, we believe our model did examine the relationship between insulin administration, glycemia, and mortality, and was not confounded by severity of illness. Furthermore, because the predicted odds ratios of death attributable to insulin administration were the same in each glycemic band examined, it is highly unlikely that our results simply reflect insulin resistance.

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