Scientists who previously generated intestinal tissue from induced pluripotent stem cells in vitro now show that these 3-dimensional organ-like structures, or organoids, are functional when transplanted into immunocompromised mice (Watson CL et al. Nat Med. doi:10.1038/nm.3737 [published online October 19, 2014]). The organoids could also be generated from embryonic stem cells, according to the team led by investigators at Cincinnati Children’s Hospital Medical Center.
Hampton T. Stem Cell–Derived Organoids Are Functional in Vivo. JAMA. 2014;312(21):2202. doi:10.1001/jama.2014.16230