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Comment & Response
December 3, 2014

Standard vs Enriched High Protein Enteral Nutrition in the ICU

Author Affiliations
  • 1Department of Surgery, VU University Medical Center, Amsterdam, the Netherlands
JAMA. 2014;312(21):2288-2289. doi:10.1001/jama.2014.14493

To the Editor Dr van Zanten and colleagues1 reported on a study of the effects of immune-enhancing nutrition involving patients in the intensive care unit; however, some of their statements on mortality are misleading.

First, the sample size of 300 was calculated based on a reduction in new infections from 25% to 12.5%. This is a reduction of 50%, not 12.5% as the authors stated. Is this a realistic reduction?

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