Letters Section Editor: Stephen J. Lurie,
MD, PhD, Senior Editor.
To the Editor: Although Dr Nissen and colleagues1 found a 4.2% mean reduction in atheroma, this number
is actually substantially less than what has been observed in animal studies.
For instance, my colleagues and I reported that a 90-minute infusion of 1
g of recombinant protein in rabbits resulted in a 30% mean reduction of plaque
Sirtori CR. ApoA-1 Milano and Regression of Atherosclerosis. JAMA. 2004;291(11):1319-1320. doi:10.1001/jama.291.11.1319-b