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March 17, 2004

ApoA-1 Milano and Regression of Atherosclerosis

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2004;291(11):1319-1320. doi:10.1001/jama.291.11.1319-b

To the Editor: Although Dr Nissen and colleagues1 found a 4.2% mean reduction in atheroma, this number is actually substantially less than what has been observed in animal studies. For instance, my colleagues and I reported that a 90-minute infusion of 1 g of recombinant protein in rabbits resulted in a 30% mean reduction of plaque volume.2

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