Letters Section Editor: Stephen J. Lurie,
MD, PhD, Senior Editor.
In Reply: We agree with Dr Osman that the brain
is an important site of potential metastatic spread. The head was part of
the imaging field of view in all patients, and data analysis included assessment
of the brain and skull. Thus, metastases to the brain and skull contributed
to the assessment of the M-stage by the 2 imaging procedures. While bone metastases
(including metastases to the skull) were evaluated separately in addition
to the overall M-stage, the number of patients with metastases to the brain
was too small for separate data analysis.
Antoch G, Ruehm SG. Whole-Body Imaging for Cancer Staging—Reply. JAMA. 2004;291(11):1320. doi:10.1001/jama.291.11.1320-c