Letters Section Editor: Stephen J. Lurie,
MD, PhD, Senior Editor.
To the Editor: Dr Clyde and colleagues1 concluded that treatment of primary hypothyroidism
with combination levothyroxine plus liothyronine was not superior to levothyroxine
alone in terms of body weight, serum lipid levels, hypothyroid symptoms, or
cognitive performance. Although Clyde et al recommend that patients should
be treated with synthetic thyroid on the basis of cost, natural desiccated
thyroid is considerably less expensive. Thus, perhaps this would be the most
rational treatment choice.
Lichten EM. Synthetic Thyroxine vs Dessicated Thyroid. JAMA. 2004;291(12):1445. doi:10.1001/jama.291.12.1445-a