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April 7, 2004

Cardiovascular Effects of Ephedra

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2004;291(13):1560. doi:10.1001/jama.291.13.1560-b

To the Editor: Dr McBride and colleagues1 suggested that ephedra might be responsible for prolongation of the QT interval, increased P-wave duration, and elevated systolic blood pressures noted with the use of Metabolife 356. The authors acknowledged that the multi-ingredient nature of this product precludes a definite statement regarding causation but argued that the findings were unlikely to be due to caffeine. They did not discuss the other components of the supplement.

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