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April 7, 2004

Screening and Treatment for Subclinical Thyroid Disease

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2004;291(13):1562. doi:10.1001/jama.291.13.1562-a

To the Editor: In their Scientific Review and Clinical Applications article about subclinical thyroid disease, Dr Surks and colleagues1 stated that numerous small studies reveal subtle decreases in myocardial contractility in patients with subclinical hypothyroidism. Although the authors cited our review article2 in making this claim, they did not mention that we found diastolic dysfunction to be the most consistent cardiac abnormality in this disease. Furthermore, we reported that it tends to regress with replacement of thyroid hormone. This finding has been independently reported elsewhere.24

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