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Medical News and Perspectives
April 14, 2004

Biological Clock Ticks for Men, Too

JAMA. 2004;291(14):1683-1685. doi:10.1001/jama.291.14.1683

Women approaching middle age have long been aware that the consequences of a ticking biological clock include not only decreased fertility but also a sharp increase in the odds of delivering a child with Down syndrome. Older men, seemingly untouched by such biological constraints, felt free to father children as they entered middle, and even old, age.

But now it is becoming increasingly clear that the biological clock ticks for men as well as women, as researchers turn up evidence that as would-be fathers get older, they have an increased chance of passing on genetic defects to their children.

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