Letters Section Editor: Stephen J. Lurie,
MD, PhD, Senior Editor.
To the Editor: Dr Greenland and colleagues1 reported that both the Framingham Risk Score (FRS)
and the coronary artery calcium score (CACS) were predictive of coronary artery
disease. The authors also reported that across categories of FRS, CACS was
predictive of risk among patients with an FRS higher than 10%, but not with
an FRS less than 10%. Furthermore, the CACS was less predictive than the FRS
(hazard ratio, 3.9 vs 14.3), and only added slightly to the area under the
receiver operating characteristic (ROC) curve using FRS alone.
Wierzbicki AS, Twomey PJ, Reynolds TM. Use of Coronary Calcification Scores to Predict Coronary Heart Disease. JAMA. 2004;291(15):1831. doi:10.1001/jama.291.15.1831-a