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April 21, 2004

Use of Coronary Calcification Scores to Predict Coronary Heart Disease

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2004;291(15):1831. doi:10.1001/jama.291.15.1831-b

To the Editor: We have several concerns about the study by Dr Greenland and colleagues.1 First, the authors emphasized the lack of association between the CACS and risk among persons with an FRS less than 10%. In fact, such an interaction would be difficult to detect, and this study adds little evidence, given the low number of persons in the study with an FRS less than 10% (n = 98) and the low number of events in that subgroup (n = 1). Furthermore, measurement of the CACS in this low-risk subgroup is unlikely to be cost-effective.2

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