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April 28, 2004

Ranolazine as Add-on Therapy for Patients With Severe Chronic Angina—Reply

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2004;291(16):1959. doi:10.1001/jama.291.16.1959-c

In Reply: In response to Drs Hooper and Busti, the improvements in exercise performance due to ranolazine in our study, as well as the magnitude of the placebo effect, are similar to those reported in studies of other widely prescribed antianginal drugs.1 In an earlier cross-over study of immediate-release ranolazine 400 mg twice daily vs atenolol 100 mg/d vs placebo, ranolazine at plasma concentrations similar to those in our study produced increases in exercise performance that were as large or larger than those effected by atenolol.2

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