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May 5, 2004

Migraine as a Risk Factor for Subclinical Brain Lesions—Reply

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2004;291(17):2072. doi:10.1001/jama.291.17.2072-b

In Reply: Dr Zaidat is concerned about overfitting of our statistical model. In fact, when we adjusted only for age, education, and study site (model 1), the results were similar to when we adjusted for additional variables (model 2). Second, we concluded that migraine may increase the risk for silent brain lesions based on both the analyses of white matter lesions and detection of cerebellar infarcts. In the statistical analysis methods section we presented a power analysis for the infarcts. Our outcome was not the total number of brain lesions.

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