Letters Section Editor: Stephen J. Lurie,
MD, PhD, Senior Editor.
In Reply: Dr Zaidat is concerned about overfitting
of our statistical model. In fact, when we adjusted only for age, education,
and study site (model 1), the results were similar to when we adjusted for
additional variables (model 2). Second, we concluded that migraine may increase
the risk for silent brain lesions based on both the analyses of white matter
lesions and detection of cerebellar infarcts. In the statistical analysis
methods section we presented a power analysis for the infarcts. Our outcome
was not the total number of brain lesions.
Kruit MC, van Buchem MA, Ferrari MD, Launer LJ. Migraine as a Risk Factor for Subclinical Brain Lesions—Reply. JAMA. 2004;291(17):2072. doi:10.1001/jama.291.17.2072-b